Allen George "Harmonica" Smith was born on April 22, 1924 in West Helena, Arkansas. His family moved to Cairo, IL soon afterward, where he was raised. Starting harp at a young age under the tutelage of his mother, George played at local parties, juke joints, and in the streets. By his teens, he moved away from home traveling through the south. 1949 saw George move to Chicago where he started working with a young Otis Rush, both playing in a style similar to the Muddy Waters band at the time.

In late 1954, the blues harmonica world would never be the same after "Little" George Smith recorded his landmark records on the RPM label. Classics such as the chromatic masterpiece "Blues In The Dark", the slow third-position techniques of "Telephone Blues", "Oopin' Doopin' Doopin'" which featured some more swinging chromatic harp, and "Blues Stay Away". Third position on chromatic and diatonic harmonica has been done before, but nothing like this.

Little Walter, the unofficial king of blues harmonica, had played third position on chromatic and diatonic harmonica, but his techniques were different. George made full use of the harmonica's tuning by his incorporation of the use of playing "octaves", especially on the chromatic. George took his blues influences and met them with his other harmonica influences (he often cited Larry Adler as his favorite) and ran with it until he developed his own approach to tone and phrasing. Besides his classic RPM sides "Blues In The Dark", "Oopin' Doopin' Doopin'" and "Down in New Orleans", other chromatic features of his include "Hawaiian Eye", "Blue Fog" and "Soul Feet". His mastery of the chromatic harmonica influenced every blues player that has picked up the instrument since, either directly or indirectly, arguably even more so than Little Walter's chromatic technique.

The late 1960's saw George coming into the spotlight a bit more after a quiet period in the early/mid 60's. Contemporary players like Charlie Musselwhite and Rod Piazza would learn as much as they could from George, and Rod even would perform in the band Bacon Fat along with George. Several great albums came out of this period, including "Tribute To Little Walter", "...of the Blues", "Arkansas Trap" and "No Time For Jive".

In the 1970's, another young harp player came into George's life that would go on be another of his greatest students - William Clarke. For the remainder of his life, George continued to perform with his band, as a sideman, or with one of his protégés, and made some great recordings even in the 70's and 80's. His influence can still be heard in the playing of the top harp players on the contemporary scene, such as Rod Piazza, Kim Wilson, Rick Estrin, Paul Delay and Mark Hummel.